2. Signaling Pathways
  3. Immunology/Inflammation
  4. PGE synthase

PGE synthase

Prostaglandin E synthase

PGE synthase

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PGE synthase (Prostaglandin E synthase), which converts cyclooxygenase (COX)-derived prostaglandin H2 (PGH2) to PGE2, is known to comprise a group of at least three structurally and biologically distinct enzymes. There are membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES).

mPGES-1 is a perinuclear protein that is markedly induced by proinflammatory stimuli and downregulated by anti-inflammatory glucocorticoids as in the case of COX-2. It is functionally coupled with COX-2 in marked preference to COX-1. mPGES-2 is synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. This enzyme is rather constitutively expressed in various cells and tissues and is functionally coupled with both COX-1 and COX-2. cPGES is constitutively expressed in a wide variety of cells and is functionally linked to COX-1 to promote immediate PGE2 production.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-144237
    BRP-201
    Brp-201 is considered as a promising therapeutic target for the next generation of anti-inflammatory drugs in the research of inflammatory diseases. It is a new, effective and selective inhibitor of mPGES-1 with an IC50 value of 0.42 μM.
    BRP-201
  • HY-162425
    Anti-inflammatory agent 78
    		Inhibitor
    Anti-inflammatory agent 78 (compound L-37) is a potent anti-inflammatory agent. Anti-inflammatory agent 78 has significant potency on PGE2/1 and COX-2/1 inhibition. Anti-inflammatory agent 78 can inhibits NO release in LPS-stimulated RAW 264.7 cell line.
    Anti-inflammatory agent 78
  • HY-126898
    5-LO/mPGES1-IN-1
    		Inhibitor
    5-LO/mPGES1-IN-1 (Compound 16) is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) and 5-lipoxygenase (5-LO). IC50 values are 0.3 and 0.4 μM, respectively. 5-LO/mPGES1-IN-1 has anti-inflammatory activity.
    5-LO/mPGES1-IN-1
  • HY-N0297R
    Sinensetin (Standard)
    		Inhibitor
    Sinensetin (Standard) is the analytical standard of Sinensetin. This product is intended for research and analytical applications.
    Sinensetin (Standard)
  • HY-105939
    Isofezolac
    		Inhibitor
    Isofezolac (LM 22070) is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin-synthetase. Isofezolac anti-inflammatory, and antipyretic properties.
    Isofezolac
  • HY-118282
    mPGES1-IN-7
    		Inhibitor 99.78%
    mPGES-1-IN-2 (compound III) is a benzimidazole-based mPGES-1 inhibitor that also inhibits adipophysin PGD synthase (I-PGDS) (5 μM, IR=60 %). mPGES-1-IN-2 reduces PGE2 production and tends to reduce levels of other prostaglandins. mPGES-1-IN-2 effectively inhibits acute inflammation in an air sac model stimulated by Carrageenan (HY-125474) in mice.
    mPGES1-IN-7
  • HY-30235AR
    Benzydamine hydrochloride (Standard)
    		Inhibitor
    Benzydamine (hydrochloride) (Standard) is the analytical standard of Benzydamine (hydrochloride). This product is intended for research and analytical applications. Benzydamine hydrochloride is a prostaglandin synthase inhibitor, anti-inflammatory, and has also been reported to have antibacterial activity.
    Benzydamine hydrochloride (Standard)
  • HY-130356
    5-trans U-46619
    		Inhibitor
    5-trans U-46619 is a PGE synthase inhibitor. At a concentration of 10 μM, 5-trans U-46619 inhibits PGE synthase by <20%.
    5-trans U-46619
  • HY-B0550R
    Bismuth Subsalicylate (Standard)
    		Inhibitor
    Bismuth Subsalicylate (Standard) is the analytical standard of Bismuth Subsalicylate. This product is intended for research and analytical applications. Bismuth Subsalicylate is a potent and orally active antacid and anti-diarrheal agent. Bismuth Subsalicylate reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin synthesis in vivo. Bismuth Subsalicylate is widely used for the research of diarrheal disorders, including indigestion, diarrhoea, nausea, et al.
    Bismuth Subsalicylate (Standard)
  • HY-W268542
    4-Acetylaminoantipyrine
    		Inhibitor
    4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX). 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation.
    4-Acetylaminoantipyrine
  • HY-139171
    F092
    		Inhibitor 99.79%
    F092 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS) with a KD value of 0.14 nM. F092 can be used in the study of allergic and inflammatory responses.
    F092
  • HY-W011309
    1-O-Hexadecylglycerol
    		Inhibitor
    1-O-Hexadecylglycerol can up-regulate PPAR-γ expression, inhibit pGE2, and exhibit anti-inflammatory properties. 1-O-Hexadecylglycerol is effective in oral administration.
    1-O-Hexadecylglycerol
  • HY-30235
    Benzydamine
    Benzydamine is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties; selectively binds to prostaglandin synthetase. Benzydamine can inhibit tumor necrosis factor-α, stabilize cell membranes, and reduce oxidative stress in cells.
    Benzydamine
  • HY-B0683S
    Limaprost-d3
    		Agonist
    Limaprost-d3 (17α,20-dimethyl-δ2-PGE1-d3) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research[1][2].
    Limaprost-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity